The Genomic Fingerprints of Lung Cancer Shape Response to Immunotherapy
Title
The Genomic Fingerprints of Lung Cancer Shape Response to Immunotherapy
Subject
Information visualization
Cancer
Immunotherapy
Description
The intersection of cancer genomics with novel immunotherapies is revolutionizing patient care. The number of mutations found in tumors has been associated with overall survival of lung cancer patients treated with immunotherapy. Inspired by these findings, I used clinical and genomic data from a lung cancer patient cohort to build a 3D information visualization and illustrate this association. Certain demographics and patient characteristics are incorporated in this visualization. I have also developed a smaller prototype for demonstration purposes, an image of which is shown on the right bottom corner of this handout.
The sketch below shows patients’ overall survival (y-axis) versus the number of mutations (x- and z-axis); the wire balls and vertical strings represent the patients and their overall survival, respectively. The small prototype mirrors the 3D information visualization structure in terms of data and materials used. First, the wire balls are color-coded based on the smoking status (black for current or former smokers and blue for non-smokers). Second, the two blocks at the top of each wire ball represent race (yellow for Asians, black for African Americans, and white for Caucasians) and gender (purple for Females and light blue for Males). Third, the blue wire cover represents patient’s overall survival, the black wire cover signifies a death event, and the white wire cover indicates that the patient was still alive when data was collected.
This work visually supports the notion that a high number of mutations may confer a survival benefit for lung cancer patients treated with immunotherapy. I am envisioning that this work may catalyze a communication channel between patients and researchers.
The sketch below shows patients’ overall survival (y-axis) versus the number of mutations (x- and z-axis); the wire balls and vertical strings represent the patients and their overall survival, respectively. The small prototype mirrors the 3D information visualization structure in terms of data and materials used. First, the wire balls are color-coded based on the smoking status (black for current or former smokers and blue for non-smokers). Second, the two blocks at the top of each wire ball represent race (yellow for Asians, black for African Americans, and white for Caucasians) and gender (purple for Females and light blue for Males). Third, the blue wire cover represents patient’s overall survival, the black wire cover signifies a death event, and the white wire cover indicates that the patient was still alive when data was collected.
This work visually supports the notion that a high number of mutations may confer a survival benefit for lung cancer patients treated with immunotherapy. I am envisioning that this work may catalyze a communication channel between patients and researchers.
Creator
Taxiarchis Botsis, Information Visualization MPS 2018
Date
2019-01-02
Rights
Photograph by Decker Library. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. For digital surrogates utilize the rights statement provided by DIU.
Language
English
Files
Collection
Citation
Taxiarchis Botsis, Information Visualization MPS 2018 , “The Genomic Fingerprints of Lung Cancer Shape Response to Immunotherapy,” Decker Library Exhibits and Displays, accessed May 4, 2024, https://deckerlibrary.omeka.net/items/show/76.